463 Results for "

Paris polyphylla Smith var. chinensis (Franch.) Hara

" in MedChemExpress (MCE) Product Catalog:
Products (463)

463 Results for "Paris polyphylla Smith var. chinensis (Franch.) Hara" in MCE Product Catalog:

25
Wedelolactone
Wedelolactone
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25 Publications Verification
Cat. No.: HY-N0551
CAS No.: 524-12-9
Category:  

Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae Disease Research Fields Inflammation/Immunology

Target:  

Caspase Lipoxygenase Apoptosis

Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC50 of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .
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20
Geniposide
Geniposide
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20 Cited Publications
Cat. No.: HY-N0009
CAS No.: 24512-63-8
Category:  

Iridoids Terpenoids Rubiaceae Plants Gardenia jasminoides Ellis

Target:  

Amyloid-β Influenza Virus

Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.
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12
AFN-1252
AFN-1252
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12 Cited Publications
Cat. No.: HY-16911
CAS No.: 620175-39-5
Synonyms: API-1252; Debio 1452
Target:  

Bacterial Antibiotic

Research Areas:  

Infection

AFN-1252 is an orally active and selective inhibitor of FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus spp. AFN-1252 exhibits exquisite and highly selective activity against Staphylococcus spp. AFN-1252 exhibits typical MIC90 values of ⩽0.015 μg/ml against diverse clinical isolates of S. aureus. AFN-1252 is efficacious in a mouse model of septicemia providing 100% protection from an otherwise lethal peritoneal infection of S. aureus Smith .
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12
Schisandrin B
Schisandrin B
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12 Cited Publications
Cat. No.: HY-N0089
CAS No.: 61281-37-6
Synonyms: γ-Schisandrin; Wuweizisu B
Category:  

Neurological Disease Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

Autophagy Reactive Oxygen Species (ROS)

Schisandrin B (γ-Schisandrin) is a biphenylcyclooctadiene derivative isolated from Schisandra chinensis and has been shown to have antioxidant effects on the liver and heart of rodents.
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10
Chaetocin
Chaetocin
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10 Cited Publications
Cat. No.: HY-N2019
CAS No.: 28097-03-2
Category:  

Infection Alkaloids Microorganisms Disease Research Fields Alkaloid Dimers

Target:  

Histone Methyltransferase Bacterial Antibiotic

Chaetocin is a specific inhibitor of the histone methyltransferase (HMT) SU(VAR)3-9 with an IC50 of 0.6 μM for SU(VAR)3-9. It also inhibits thioredoxin reductase (TrxR) with an IC50 of 4 μM.
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9
GGTI298 Trifluoroacetate
GGTI298 Trifluoroacetate
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9 Cited Publications
Cat. No.: HY-15871
CAS No.: 1217457-86-7
Purity:  99.61%
Target:  

Apoptosis

Research Areas:  

Cancer

GGTI298 Trifluoroacetate is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, which can inhibit Rap1A with IC50 of 3 μM; little effect on Ha-Ras with IC50 of >20 μM.
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5
Polyphyllin I
Polyphyllin I
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5 Cited Publications
Cat. No.: HY-N0047
CAS No.: 50773-41-6
Category:  

Liliaceae Paris polyphylla Smith Plants Disease Research Fields Saccharides Cancer Steroids

Target:  

JNK mTOR Akt PDK-1 Autophagy Apoptosis

Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis .
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5
Paris saponin VII
Paris saponin VII
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5 Cited Publications
Cat. No.: HY-N3584
CAS No.: 68124-04-9
Synonyms: Chonglou Saponin VII
Category:  

Liliaceae  Trillium tschonoskii Maxim. Plants Disease Research Fields Cancer Steroids

Target:  

Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis

Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .
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5
Schisandrin C
Schisandrin C
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5 Cited Publications
Cat. No.: HY-N0690
CAS No.: 61301-33-5
Synonyms: Schizandrin-C; Wuweizisu-C
Category:  

Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

Apoptosis

Schisandrin C (Schizandrin-C) is a phytochemical lignan isolated from Schizandra chinensis . Schisandrin C has diverse biological activities, including anticancer, anti-inflammatory and antioxidant effects. Schisandrin C can be used for cancer, alzheimer’s disease, and liver diseases research . Schisandrin C induces cell apoptosis .
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5
Coptisine Sulfate
Coptisine Sulfate
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5 Cited Publications
Cat. No.: HY-N0430A
CAS No.: 1198398-71-8
Category:  

Alkaloids Chelidonium majus Metabolic Disease Quinoline Alkaloids Plants Disease Research Fields Papaveraceae

Target:  

Indoleamine 2,3-Dioxygenase (IDO) NF-κB p38 MAPK PI3K Akt Apoptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism DNA/RNA Synthesis ROCK LDLR

Coptisine Sulfate is an orally active and brain-penetrant alkaloid found in Coptis chinensis. Coptisine Sulfate is a reversible, uncompetitive IDO inhibitor with a Ki of 5.8 μM and an IC50 of 6.3 μM. Coptisine Sulfate suppresses neuroinflammation, reduces Aβ plaque burden and shows neuroprotective activity. Coptisine Sulfate shows anti-inflammation activity by blocking NF-κB, MAPK, and PI3K/Akt activation. Coptisine Sulfate inhibits cancer cells proliferation, induces DNA damage, G2/M phase cell cycle arrest, apoptosis, ROS production and mitochondrial dysfunction. Coptisine Sulfate inhibits Rho/ROCK pathway activation, reduces arrhythmia, limits cardiac injury marker release, reduces infarct size, and preserves cardiac function in rat myocardial ischemia/reperfusion models. Coptisine Sulfate downregulates HMGCR and upregulates LDLR and CYP7A1 to modulate cholesterol metabolism, reduces abnormal serum lipid levels, and promotes fecal bile acid excretion. Coptisine Sulfate be used for the research of cancer, hypercholesterolemia, Alzheimer’s disease, inflammatory disorders and cardiovascular disease .
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4
Schisandrin
Schisandrin
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4 Cited Publications
Cat. No.: HY-N0691
CAS No.: 7432-28-2
Synonyms: Schizandrin; Schizandrol; Schizandrol-A
Category:  

Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

Autophagy

Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .
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4
Corosolic acid
Corosolic acid
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4 Cited Publications
Cat. No.: HY-N0280
CAS No.: 4547-24-4
Synonyms: Colosolic acid
Category:  

Triterpenes other families Terpenoids Plants Disease Research Fields Cancer

Target:  

Autophagy Apoptosis EGFR

Corosolic acid (Colosolic acid) isolated from the fruit of Cratoegus pinnatifida var. psilosa, was reported to have anticancer activity. Corosolic acid induces cancer cell apoptosis .
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4
Irisflorentin
Irisflorentin
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4 Cited Publications
Cat. No.: HY-N0268
CAS No.: 41743-73-1
Category:  

Iridaceae Flavonoids Plants Belamcanda chinensis (Linn.) Redouté Disease Research Fields Inflammation/Immunology Isoflavones

Target:  

NO Synthase

Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Belamcanda chinensis. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity .
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4
Epiberberine chloride
Epiberberine chloride
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4 Cited Publications
Cat. No.: HY-N0226A
CAS No.: 889665-86-5
Category:  

Alkaloids Neurological Disease Ranunculaceae Coptis chinensis Franch. Metabolic Disease Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

Cholinesterase (ChE) Beta-secretase Reactive Oxygen Species (ROS)

Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO - scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease . Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways . Epiberberine has the potential effect in the research of diabetic disease .
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3
Leucocyanidin
Leucocyanidin
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3 Cited Publications
Cat. No.: HY-119580
CAS No.: 480-17-1
Purity:  98.03%
Category:  

Litchi Chinensis Sonn. Plants Flavonoids Microorganisms Flavanols Sapindaceae Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:  

Others

Leucocyanidin is an active anti-ulcerogenic ingredient was extracted from Litchi Chinensis. Leucocyanidin demonstrates a significant protective effect against Aspirin-induced erosions in rat models .
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3
Atractylodin
Atractylodin
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3 Cited Publications
Cat. No.: HY-N0238
CAS No.: 55290-63-6
Synonyms: Atractydin
Category:  

Infection Natural Products Plants Compositae Disease Research Fields Erythrina sigmoidea Hua

Target:  

Insecticide

Atractylodin (Atractydin) is an orally active active ingredient obtained from the rhizome of Atractylodes lancea and A. chinensis. Atractylodin is a natural insecticide. Atractylodin has anti-inflammatory activity .
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3
Jatrorrhizine chloride
Jatrorrhizine chloride
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3 Cited Publications
Cat. No.: HY-N0740
CAS No.: 6681-15-8
Category:  

Alkaloids Monophenols Ranunculaceae Coptis chinensis Franch. Phenols Plants Isoquinoline Alkaloids

Target:  

Cholinesterase (ChE) 5-HT Receptor Bacterial

Jatrorrhizine chloride is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine chloride is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .
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3
Jatrorrhizine hydroxide
Jatrorrhizine hydroxide
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3 Cited Publications
Cat. No.: HY-N0749A
CAS No.: 483-43-2
Category:  

Alkaloids Monophenols Ranunculaceae Coptis chinensis Franch. Phenols Plants Isoquinoline Alkaloids

Target:  

Cholinesterase (ChE) 5-HT Receptor Bacterial

Jatrorrhizine hydroxide is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .
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3
Gomisin J
Gomisin J
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3 Cited Publications
Cat. No.: HY-N0385
CAS No.: 66280-25-9
Category:  

Cardiovascular Disease Monophenols Lignans Phenols Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill.

Target:  

NO Synthase AMPK CaMK NF-κB Keap1-Nrf2

Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc .
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2
Schisandrol B
Schisandrol B
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2 Cited Publications
Cat. No.: HY-N0692
CAS No.: 58546-54-6
Synonyms: Gomisin-A; TJN-101; Wuweizi alcohol-B
Category:  

Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

Reactive Oxygen Species (ROS) Cytochrome P450 Autophagy

Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .
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